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How Memories Are Made, And Recalled

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What makes a memory? Single cells in the brain, for one thing.

For the first time, scientists at UCLA and the Weizmann Institute of Science in Israel have recorded individual brain cells in the act of calling up a memory, thus revealing where in the brain a specific memory is stored and how the brain is able to recreate it.

Reporting in the current online edition of the journal Science, Dr. Itzhak Fried, senior study author and a UCLA professor of neurosurgery, and colleagues recorded the activity of hundreds of individual neurons making memories in the brains of 13 epilepsy patients being treated surgically at UCLA Medical Center.

Surgeons had placed electrodes in the patients’ brains to locate the origin of their seizures before surgical treatment — standard procedure in such cases. Fried made use of the same electrodes to record neuron activity as memories were being formed.

The patients watched several video clips of short duration, including such things as landmarks and people, along with other clips of Jerry Seinfeld, Tom Cruise, “Simpsons” character Homer Simpson and others. As the patients watched, the researchers recorded the activity of many neurons in the hippocampus and a nearby region known the entorhinal cortex that responded strongly to individual clips.

A few minutes later, after performing an intervening task, the patients were asked to recall whatever clips came to mind.

“They were not prompted to recall any specific clips,” Fried said, “but to use ‘free recall’ — that is, whatever popped into their heads.”

The researchers found that the same neurons that had responded earlier to a specific clip fired strongly a second or two before the subject reported recalling that clip. These neurons did not fire, however, when other clips were recalled. Ultimately, it was possible for the researchers to know which clip a patient was recalling before the patient announced it.

Fried noted that the single neurons that were recorded as they fired were not acting alone but were part of a much larger memory circuit of hundreds of thousands of cells caught in the act of responding to the clips.

The study is significant, he said, because it confirms for the first time that spontaneous memories arise through the activity of the very same neurons that fired when the memory was first being made. This link between reactivation of neurons in the hippocampus and conscious recall of past experience has been suspected and theorized for sometime, but the study now provides direct evidence for such a link.

“In a way, then,” Fried said, “reliving past experience in our memory is the resurrection of neuronal activity from the past”

Science, 2008; DOI: 10.1126/science.1164685
Internally Generated Reactivation of Single Neurons in Human Hippocampus During Free Recall.
Hagar Gelbard-Sagiv, Roy Mukamel, Michal Harel, Rafael Malach, and Itzhak Fried

The emergence of memory, a trace of things past, into human consciousness is one of the greatest mysteries of the human mind. Whereas the neuronal basis of recognition memory can be probed experimentally in human and nonhuman primates, the study of free recall requires that the mind declare the occurrence of a recalled memory (an event intrinsic to the organism and invisible to an observer). Here, we report the activity of single neurons in the human hippocampus and surrounding areas when subjects first view television episodes consisting of audiovisual sequences and again later when they freely recall these episodes. A subset of these neurons exhibited selective firing, which often persisted throughout and following specific episodes for as long as 12 seconds. Verbal reports of memories of these specific episodes at the time of free recall were preceded by selective reactivation of the same hippocampal and entorhinal cortex neurons. We suggest that this reactivation is an internally generated neuronal correlate of the subjective experience of spontaneous emergence of human recollection.

Written by huehueteotl

September 17, 2008 at 7:30 am

Posted in Neuroscience

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